Membrane Integrity during the Co‐translational Integration of Multi‐spanning Membrane Proteins
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چکیده
منابع مشابه
The Cotranslational Integration of Membrane Proteins into the Phospholipid Bilayer Is a Multistep Process
During the cotranslational integration of a nascent protein into the endoplasmic reticulum membrane, the transmembrane (TM) sequence moves out of an aqueous pore formed by Sec61alpha, TRAM, and other proteins and into the nonpolar lipid bilayer. Photocross-linking reveals that this movement involves the sequential passage of the TM domain through three different proteinaceous environments: one ...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2006
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.20.5.a890